Combinatorial chemistry is a technique that allows for the simultaneous synthesis of a large number of compounds by combining a small number of starting materials in various combinations. This methodology has been developed as an alternative approach for chemical customization in drug discovery. Combinatorial chemistry provides several potential applications, including the exploration of chemical space to find novel chemical entities, as well as the generation of diverse sets of molecules that preserve property distributions while increasing structural diversity. Additionally, it allows for the time- and cost-efficient discovery of compounds that are highly active against specific disease targets, such as the malaria parasite. Combinatorial chemistry has given chemists access to vast numbers of molecules for creating compound libraries to screen for novel leads or optimizing the activity and properties of known compounds. The advancements in combinatorial chemistry have also driven the development of automated methods for reaction design, synthesis, analysis, and testing, enabling the realization of its full potential not only in pharmaceutical research but also in catalyst development, materials research, and other areas. #DrugDiscovery #ChemicalCustomization #CombinatorialChemistry